Objective The purpose of this study is to investigate the status and influencing factors of financial toxicity（FT） in patients with prostate cancer,and to provide a basic theory for reducing FT levels in prostate cancer patients. Methods With the convenience sampling method,a total of 281 prostate cancer patients were recruited from a hospital in Shanghai from January 2020 to August 2021. A cross-sectional study was conducted by the general data questionnaire,the Comprehensive Scores for Financial Toxicity based on the Patient-Reported Outcome Measures（COST-PROM）,the Medical Coping Modes Questionnaire（MCMQ） and the General Self-Efficacy Scale（GSES）. Besides,multiple linear regression was used to identify predictors of FT in patients with prostate cancer. Results The total score of COST-PROM was 22.0 （17.0,24.0）. Multiple linear regression analysis showed that the factors of the diagnosis of prostate cancer affecting the retirement age,the average income per person in family,the treatment cost in the last 3 months,the dimension of surrender in medical coping style and the level of self-efficacy were the main influencing factors of FT（P<0.001）,which accounted for 45.6% of total variation. Conclusion The FT of patients with prostate cancer is in the middle and low level. Clinical staff should use the effective intervention measures to help patients go back to work,estimate their economic conditions for choosing individualized treatment,help them seek more social supports and resources,and guide them to manage problems in positive ways and enhance the level of self-efficacy,in order to reduce the level of FT and improve the quality of their life.

Objective To summarize the experience of prevention and control management in a hemodialysis centers during the coronavirus disease 2019（COVID-19） epidemic,and to improve the effects in order to reduce the occurrence of COVID-19 infection. Methods Through developing the standards for prevention and control of COVID-19 in hemodialysis centers,267 hemodialysis centers in Zhejiang province were trained in the aspects of organization management,prevention and control procedures,patient education and management,staff training and management. We also standardize the diagnosis procedures of hemodialysis during the COVID-19 epidemic,and standardize the isolated hemodialysis procedures of confirmed cases,suspected cases and patients observed at home. Results There were 2 confirmed COVID-19 cases out of 32071 hemodialysis patients in Zhejiang Province,and 10 hemodialysis patients in close contact with them were also taking isolation dialysis. No COVID-19 infection occurred after medical observation of 14 days. There were also no infections after 14 days’ medical observation among 8 suspected cases and 78 home observation patients who were treated with standard isolation dialysis or continuous renal replacement therapy. None of the 4 700 medical staff suffered from the nosocomial infections of COVID-19. Conclusion The practice in hemodialysis centers is effective in preventing and controlling the COVID-19 infection in the provincial hemodialysis centers, which can reduce or even block the infection in hemodialysis patients